Scientific studies

Since its inception, the PronoKal Group®, which owns the PronoKal® Method, has been committed to scientific research and a thorough approach. The company is therefore the driving force behind numerous studies whose objectives are to demonstrate the safety and efficacy of the method in the short and long term. The results of these studies, which are very positive, are presented at major scientific conferences and international forums, with the help of renowned speakers.

The main studies and clinical trials are:

  • 2016. Body composition changes after very low-calorie ketogenic diet in obesity evaluated by three standardized methods. The Journal Clinical Endocrinology & Metabolism (JCEM). The main objective is to evaluate the very low-calorie-ketogenic (VLCK) diet-induced changes in body composition of obese patients and to compare three different methodologies employed to evaluate that changes. Diego Gomez-Arbelaez, Diego Bellido, Ana I. Castro, Lucia Ordoñez-Mayan, Jose Carreira, Cristobal Galban, Miguel A. Martinez-Olmos, Ana B. Crujeiras, Ignacio Sajoux, Felipe F. Casanueva.  Consult the study

  • ProKal Study. Clinical trial in the Obesity Unit of the Gregorio Marañón General University Hospital (Madrid). The main objective is to evaluate the differences in weight loss among obese patients following the PronoKal® Method and those who follow a low calorie diet. 

ProKal Study (555.8 KB)

ProKal Study 12 months
ProKal Study 24 months

  • Promesa I and Promesa II. These studies were aimed at evaluating the efficacy in reducing weight and safety of the use of the PronoKal® Method in overweight and obese patients.

Promesa I Study (668.1 KB)

Promesa II Study (594.2 KB)

  • DiaproKal® Study. Clinical study to evaluate the safety of a Protein Diet versus a low-calorie diet in reducing weight in obese patients with type 2 diabetes or pre-diabetes. This study was presented at the World Diabetes Congress held in Dubai in 2011, among others.

DiaproKal Study (309.4 KB)

DiaproKal Study

  • Comparison of a common low-calorie diet and a Protein Diet (PronoKal® Method) in Mexican adults.
  • Diana Study. This study is drawing up a detailed description (demographic characteristics, comorbidities, habits, etc.) of the Patient Profile of overweight and diabetic people being treated with a Protein Diet.
  • Proce-D Study. This study aims to establish common capillary ketonemia levels in diabetic or prediabetic people undergoing weight loss by a Protein Diet.
  • Promet Study. This study was carried out internationally, in countries such as Spain, Brazil, Belgium and Argentina, and assessed weight loss and evolution of the factors related to excess weight during a Protein Diet (PronoKal® Method).
  • Systems biology and nutrition. Positive effects of a high-protein ketogenic diet in patients with type 2 diabetes, clinical evidence of the molecular basis. This study was published in the magazine "Nutrition & Metabolism" and explains why ketosis achieved by the PronoKal® Method can work in patients with type 2 diabetes.
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